解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:OBJECTIVES:Protein kinase C (PKC) is involved in cell growth, differentiation, and apoptosis. We investigated the effects of the PKC activator, the tetradecanylphorbol acetate (TPA), in human pancreatic cancer cells. METHODS:Cell proliferation was measured by thymidine incorporation. Expression of cell cycle proteins ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000226896.93945.41
更新日期:2006-08-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the tumor necrosis factor alpha (TNF-alpha) releasing capacity in whole blood stimulated by lipopolysaccharide (LPS) in patients with pancreatic cancer during the perioperative period, and before and after chemotherapy. METHODS:The current study involved a total of 39 pa...
journal_title:Pancreas
pub_type: 临床试验,杂志文章
doi:10.1097/01.mpa.0000226880.66130.79
更新日期:2006-07-01 00:00:00
abstract:OBJECTIVE:Secreted apoptosis-related protein (SARP) families are considered to counteract the oncogenic Wnt signaling pathway, and inactivation of this gene may aid cancer development and progression. Recently, the aberrant methylation of SARP2 was detected frequently in pancreatic carcinoma (PCa) tissue, but not in no...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000221617.89376.38
更新日期:2006-05-01 00:00:00
abstract:OBJECTIVES:Recent studies have shown that overexpression of S-phase kinase-associated protein 2 (Skp2) occurs in many cancers at an advanced stage. We examined the clinicopathologic significance and prognostic implication of Skp2 expression in pancreatic invasive ductal carcinoma. METHODS:Tissue samples from 46 pancre...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000220862.78248.c4
更新日期:2006-05-01 00:00:00
abstract:OBJECTIVES:Currently available pancreatic enzyme products are crude porcine products with few data available regarding their efficacy, safety, and manufacture. We conducted a phase 1 study of a novel pancreatic enzyme product, TheraCLEC-Total (TCT), a proprietary formulation of microbial-derived lipase, protease, and a...
journal_title:Pancreas
pub_type: 杂志文章,多中心研究
doi:10.1097/01.mpa.0000202952.10612.21
更新日期:2006-04-01 00:00:00
abstract::Clinical, histopathologic, immunohistochemical, and genetic analyses of 2 osteoclastic giant cell tumors of the pancreas are presented. The neoplasms were composed of osteoclastic giant cells and pleomorphic cells (PCs). The tissue-specific markers gave evidence of mesenchymal nature of the osteoclastic giant cells, a...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000202951.10612.fa
更新日期:2006-04-01 00:00:00
abstract::The hedgehog (Hh) family of genes, sonic hedgehog (Shh), Indian hedgehog (Ihh), and desert hedgehog (Dhh) encode signaling molecules that regulate multiple functions during organ development and in adult tissues. Altered hedgehog signaling has been implicated in disturbed organ development as well as in different dege...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/01.mpa.0000202937.55460.0c
更新日期:2006-03-01 00:00:00
abstract:OBJECTIVES:Prior studies have indicated that endogenous or exogenous cholecystokinin (CCK) induces transient acinar cell proliferation at about 24 hours after its stimulation. The aims of the present study were to determine the time point when the administration of the CCK-A-receptor antagonist loxiglumide had its maxi...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000202960.63977.d1
更新日期:2006-03-01 00:00:00
abstract:OBJECTIVES:An impaired host immunity might concur in determining the dismal prognosis of patients with pancreatic cancer (PC). Our aim was to ascertain whether the immunophenotype pattern of blood lymphocytes in PC correlates with tumor stage, grade, or survival. METHODS:We studied 115 patients with PC, 44 with chroni...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000188305.90290.50
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVES:Previous research has shown that the retinoid 9-cis retinoic acid (RA) promotes apoptosis in pancreatic cancer cells. The vitamin D analog EB1089 does not. Furthermore, cotreatment of cells with 9-cis RA and EB1089 abrogates apoptosis. To explain this, we studied the regulation of proteins involved in apopto...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000191648.47667.4f
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:All forms of commonly practiced enteral feeding techniques stimulate pancreatic secretion, and only intravenous feeding avoids it. In this study, we explored the possibility of more distal enteral infusions of tube feeds to see whether activation of the ileal brake mechanism can result in enteral feeding with...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000183374.11919.e5
更新日期:2005-11-01 00:00:00
abstract::The prognosis of patients with alpha-fetoprotein (AFP)-producing pancreatic cancer is generally very poor. We, however, present a case of a 33-year-old man who survived AFP-producing pancreatic cancer and its metachronous liver metastasis. The patient had undergone a curative total pancreatectomy for AFP-producing pan...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000179727.15716.82
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVES:Targeting anticancer agents to receptors for peptide hormones such as bombesin/gastrin-releasing peptide (GRP) on tumor cells increases the efficacy and lowers the toxicity of cancer therapy. We studied the expression of bombesin/GRP receptors in 6 experimental pancreatic cancers and evaluated tumor inhibiti...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000175892.97036.a7
更新日期:2005-10-01 00:00:00
abstract:OBJECTIVES:Glucagon-like peptide-1 (GLP-1) is known to stimulate glucose-dependent insulin production and secretion by pancreatic beta-cells. Preliminary evidence suggests that GLP-1 may also influence endocrine differentiation from pancreatic progenitor cells. Additionally, TGF-beta signaling can also control endocrin...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000172566.70619.58
更新日期:2005-08-01 00:00:00
abstract::A 62-year-old man underwent distal pancreatectomy for invasive pancreatic carcinoma. Histopathologically, the main lesion that obstructed the main pancreatic duct and measured 2.0 cm in diameter was a moderately differentiated adenocarcinoma with marked neural invasion. The main pancreatic duct immediately distal to t...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000168224.51332.f8
更新日期:2005-08-01 00:00:00
abstract:OBJECTIVE:Pancreatic ductal carcinoma frequently recurs postoperatively, and we analyzed clinicopathological features of patients treated by surgical resection to find predictors of postoperative recurrence. METHODS:A retrospective cohort study was performed that included 69 patients between 1985 and 2003. Clinicopath...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000166998.04266.88
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVE:Administration of multiple low doses of streptozotocin (mld-SZ) to mice results in the development of autoimmune diabetes. Hyperglycemia does not develop until a few days after the last injection. In this study, we explored immune-related alterations found in the very early stages of this diabetic syndrome an...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000161888.02244.7a
更新日期:2005-05-01 00:00:00
abstract:OBJECTIVES:We examined pancreatic cancer risk in association with hormonal and reproductive factors in a prospective cohort study of 89,835 Canadian women, aged 40-59 at recruitment, who were enrolled in the National Breast Screening Study (NBSS). METHODS:Linkages to national cancer and mortality databases yielded dat...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000160301.59319.ba
更新日期:2005-05-01 00:00:00
abstract:OBJECTIVES:In patients with pancreaticobiliary maljunction (PBM), reflux of pancreatic juice to the bile duct may contribute to carcinogenesis of the biliary tract. This study aimed to investigate the pancreatographic findings in patients with PBM and the relationship to their clinical findings in view of pancreatic ju...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000153336.50482.59
更新日期:2005-04-01 00:00:00
abstract:OBJECTIVES:The authors investigated differential expression of cdx2 in intraductal papillary mucinous neoplasm of the pancreas (IPMN) and ductal adenocarcinoma. METHODS:Patients with IPMN (n = 23) and pancreatic ductal adenocarcinoma (n = 30) were studied. Expression of cdx2 mRNA, CDX2 protein, muc2 mRNA, MUC2 apomuci...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000153615.55761.00
更新日期:2005-04-01 00:00:00
abstract:OBJECTIVES:Most of the acetaldehyde, a recognized animal carcinogen, generated during alcohol metabolism is eliminated by liver mitochondrial aldehyde dehydrogenase 2 (ALDH2). More than 40% of Japanese have the inactive form of ALDH2, and inactive ALDH2 is a risk factor for multiple cancers of the esophagus as well as ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000147084.70125.41
更新日期:2005-03-01 00:00:00
abstract:OBJECTIVES:Regeneration of the pancreas is initiated by the tubular complexes that consist of a cluster of epithelia surrounded by the mesenchymal cells. They have the potential to become pancreatic lobes, but their growth stops before the complete regeneration of the organ. To elucidate the possibility that we could p...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000150110.45017.fc
更新日期:2005-03-01 00:00:00
abstract:OBJECTIVES:Inducible nitric oxide synthase (iNOS) activity is increased in experimental acute pancreatitis. The aim of this study was to evaluate treatment with the selective iNOS inhibitors AR-C (AR-C102222AA) and L-NIL (L-N6-(1-iminoethyl)-lysine) in experimental acute pancreatitis. METHODS:Acute pancreatitis was in...
journal_title:Pancreas
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVES:Recent studies have demonstrated that synthetic protease inhibitors could ameliorate the progression of pancreatic fibrosis in some animal models. Since oral administration of protease inhibitors increases the plasma cholecystokinin (CCK) levels and causes hypertrophy of the pancreas in rats, there is a poss...
journal_title:Pancreas
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVES:Tissue desmoplasia occurs in a number of disease states, but its molecular basis is poorly understood. To determine which genes are overexpressed in cells contained within the desmoplastic stroma of pancreatic adenocarcinoma and chronic pancreatitis, we undertook genetic profiling of microdissected tissue sa...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200411000-00003
更新日期:2004-11-01 00:00:00
abstract:OBJECTIVES:During the past decade, numerous studies in both humans and animals have demonstrated that C-peptide, although not influencing blood sugar control, might play a role in preventing and potentially reversing some of the chronic complications of type 1 diabetes. The aim of this paper is to present an up-to-date...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/00006676-200410000-00009
更新日期:2004-10-01 00:00:00
abstract:OBJECTIVE:Beacon gene expression is elevated in the hypothalamus of the Israeli sand rat (Psammomys obesus), an animal that is used as a polygenic animal model of obesity and NIDDM. We performed studies aimed at investigating the expression of beacon mRNA and protein in pancreatic islets of the rat and the possible bea...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200408000-00003
更新日期:2004-08-01 00:00:00
abstract:PURPOSE:In this study we investigated the relationship between specific HLA antigens and sporadic pancreatic cancer in Greek population. METHODS:The allele frequencies of serologically and molecular defined class I and II HLA antigens were studied in 60 unrelated patients with pancreatic cancer histologically confirme...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200407000-00054
更新日期:2004-07-01 00:00:00
abstract::Type I diabetes is characterized by destruction of insulin-producing beta-islet cells in the pancreas resulting in hyperglycemia and associated morbidity. The successful treatment of diabetes by transplanted islets has resulted in renewed efforts to identify methods to augment islet availability. One approach is to id...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200407000-00064
更新日期:2004-07-01 00:00:00
abstract:OBJECTIVES:There have been various studies of exocrine pancreatic function after acute pancreatitis, but few have examined the relationship between this function and the etiology of the pancreatitis. The aim of this work was to study pancreatic function in patients who had had acute alcoholic or acute biliary pancreati...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200405000-00001
更新日期:2004-05-01 00:00:00
abstract::ATM protein anticipates in the initiation of the DNA repair signal pathway and also mediates cell cycle arrest and repair. ATM deficiency predictably results in radiosensitivity, germ cell degeneration, chromosomal instability, immunodeficiency, and an extreme predisposition to tumors. Moreover, studies found that ATM...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200405000-00011
更新日期:2004-05-01 00:00:00
abstract::Paraoxonase 1 (PON1) is an antioxidant enzyme that inhibits the oxidative modification of LDL. Since PON1 has been shown to express in pancreatic islets and oxidative stress plays a role in beta-cell dysfunction, we investigated the impact of the PON1 polymorphisms on beta-cell function. This study included 84 healthy...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200405000-00021
更新日期:2004-05-01 00:00:00
abstract::Computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET) are sophisticated modalities typically used in the second-line diagnosis following routine clinical practice. Among them, CT is regarded as the standard imaging in diagnosing pancreatic cancer at present in Japan due to ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200404000-00011
更新日期:2004-04-01 00:00:00
abstract::: Human tumor antigens recognized by T cells have been recently identified in various cancers, including pancreatic cancer. With the identified antigens, new immunotherapies can be developed using more efficient immunologic intervention (due to sufficient amounts of antigens in a more immunogenic form), as well as mor...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/00006676-200404000-00021
更新日期:2004-04-01 00:00:00
abstract:OBJECTIVES:In patients with chronic pancreatitis (cP) with an inflammatory mass in the pancreatic head, the degree of fibrosis in the pancreatic head compared with the tail should be determined and differences in the expression pattern of collagen types I, III, and IV; laminin; vitronectin; and fibronectin should be ev...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200403000-00009
更新日期:2004-03-01 00:00:00
abstract::Several reports have described a loss of endogenous antioxidants and molecular oxidative damage during acute pancreatitis. Since hyaluronic acid and chondroitin-4-sulfate possess antioxidant properties, the effect of the administration of these glycosaminoglycans in a cerulein-induced acute pancreatitis in rats was in...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200403000-00019
更新日期:2004-03-01 00:00:00
abstract::Despite the new diagnostic and therapeutic advancements, acute pancreatitis has still high rate of morbidity and mortality. We aimed to evaluate the effects of hyperbaric oxygen (HBO) therapy alone or combined with S-methylisothiourea (SMT), and meropenem (MER) therapy in an experimental rat model of acute necrotizing...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200401000-00008
更新日期:2004-01-01 00:00:00
abstract::Although ethanol abuse is the major etiologic factor in the development of acute and chronic pancreatitis, the mechanisms of ethanol effects to cause pancreatitis are poorly understood. The major reason for the lack of progress is the relative lack of animal models that reproduce the deleterious effects of ethanol on ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200311000-00004
更新日期:2003-11-01 00:00:00
abstract::Adenocarcinoma of the pancreas is one of most catastrophic and least understood of cancers. Evidence from clinical studies indicates that the development of pancreas cancer progresses over many years before symptoms appear. Most people with pancreatic cancer die within six months of diagnosis. The lack of early diseas...
journal_title:Pancreas
pub_type:
doi:10.1097/00006676-200311000-00014
更新日期:2003-11-01 00:00:00
abstract::Relative adrenal insufficiency is common in patients with severe sepsis and septic shock. We describe three patients with severe acute pancreatitis who developed signs suggestive of adrenal insufficiency during the early phase of the disease. Clinical features and possible causes of adrenal insufficiency are discussed...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200310000-00009
更新日期:2003-10-01 00:00:00